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SpatialEcoTyper 0.0.1

  • First release of SpatialEcoTyper.
    • SpatialEcoTyper: SE discovery from a single sample
    • MultiSpatialEcoTyper: Integrative analysis of SEs from multiple samples
    • IntegrateSpatialEcoTyper: Integrative analysis of SEs from multiple samples
    • RecoverSE: SE recovery
    • nmfClustering: NMF clustering
    • SpatialView: draw spatial map of the tissue
    • HeatmapView: draw a heatmap
    • CreatePseudobulks: create pseudobulk mixtures
    • NMFGenerateW: train an NMF model for SE deconvolution from bulk expression profiles
    • NMFGenerateWList: train cell-type specific NMF model for SE recovery

SpatialEcoTyper 0.0.2

  • Reduce memory usage by computing distance of spatial neighbors and not all pairwise distances

SpatialEcoTyper 0.0.3

  • Reduce memory usage by replacing Reduce() with loops
  • Add seeds to nmfClustering
  • Re-organize the documentation for integrative analysis
  • Test and refine all documentations

SpatialEcoTyper 0.0.4

  • Test Seurat v4.2, v4.4 and v5 for the analysis and add related notes: they lead to different embedding and clustering results, but show high consistency (ARI=0.7) for the demo.
  • Add more figures to the output directory for integrative analysis
  • Add hints about the training of SE recovery model: the demo is less robust due to limited number of cells used. The training data should be as comprehensive as possible.
  • Add minibatch option to SNF2 function to reduce memory usage
  • Add hints about memory usage and parallel processing

SpatialEcoTyper 0.0.5

  • Add filter.region.by.celltypes option to SpatialEcoTyper and MultiSpatialEcoTyper

SpatialEcoTyper 1.0.0

  • First release