I am afraid that I can't implement this. Since only-light and only-dark feature is implemented by CSS selector, and glightbox doesn't support dynamically add or remove images from slide.

If this lightbox effect affects your dynamic image based on the theme, you can add the class off-glb to images to disable them with the lightbox effect but keep others with it. The demo and details are both on documents.

I have also found this problem and I'm surprised that I found a solution for that, right in the document https://blueswen.github.io/mkdocs-glightbox/gallery/gallery/

So instead of

![Image title](https://dummyimage.com/600x400/f5f5f5/aaaaaa#only-light)
![Image title](https://dummyimage.com/600x400/21222c/d5d7e2#only-dark)
...
![Image title](https://dummyimage.com/600x400/f5f5f5/aaaaaa#only-light)
![Image title](https://dummyimage.com/600x400/21222c/d5d7e2#only-dark)

Add the data-gallery attribute

![Image title](https://dummyimage.com/600x400/f5f5f5/aaaaaa#only-light){data-gallery="light"}
![Image title](https://dummyimage.com/600x400/21222c/d5d7e2#only-dark){data-gallery="dark"}
...
![Image title](https://dummyimage.com/600x400/f5f5f5/aaaaaa#only-light){data-gallery="light"}
![Image title](https://dummyimage.com/600x400/21222c/d5d7e2#only-dark){data-gallery="dark"}

or any name to separate them into different galleries (in here I use light and dark.
So when you are in light mode, only the images with the attribute data-gallery="light" are displayed in the lightbox and vice versa.

This works perfectly!

@Lexachoc

Manually adding this attribute to every image element is very cumbersome for cases with a large number of images, so I've submitted a PR based on your ideas that might help with this. #49