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Bootstrap Enrichment Test For Enrichment And Depletion #95

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KevinMarinus opened this issue Oct 30, 2024 · 0 comments
Open

Bootstrap Enrichment Test For Enrichment And Depletion #95

KevinMarinus opened this issue Oct 30, 2024 · 0 comments

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@KevinMarinus
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Is your feature request related to a problem? Please describe.
When I do bootstrap enrichment tests I have for some particular usecases very strong enrichments for for example GABAergic neurons, which is accompanied by a negative 'stdevs from mean' for Glutamatergic (and/or non-neuronal) cell types - suggesting depletion for these cell types. However, this 'direction' is not tested for (nor automatically plotted; y>0).

Describe the solution you'd like
I'd like to be able to also test for this negative direction.

Describe alternatives you've considered
Although I can plot these negative values manually with ggplot, i don't have alternatives for testing it.

Additional context
Additionally, it would be nice to have a quick setting option for axes adjustments to adjust the standard bootstrap enrichment plots to negative directions and keep them consistent when making several plots.

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